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La fréquentation est exprimée en nombre de voyageurs par créneau.
La ligne 42 est exploitée avec un parc de 7 véhicules standard offrant les fréquences suivantes :
La ligne fonctionne du lundi au vendredi de 5h15 à 0h25 et les dimanches et fêtes à partir de 5h20 environ. Du lundi au samedi en soirée après 21h et les dimanches et fêtes, le tronçon entre Palettes et Carouge-Rondeau n'est pas desservi. (source Wikipédia)